top of page

Conjuran ®

Classification: Medical Devices

Component: PN (Polynucleotide)

Purpose of use: Improving elasticity, turgidy and tonicity of skin

Storage / Shelf life: Room temperature 1〜30°C 

Packing unit: 2cc / Syringe / 1pack

Rejuran Healer is a skin healing treatment that has surged in popularity over the last few months. The world cannot seem get enough of skin rejuvenating injection treatments. Skinboosters was the must-have treatment last year, but today, Rejuran Healer, from South Korea has become the treatment on everyone’s lips and minds. 

Rejuran Healer is a rejuvenating skin treatment made of biological molecules called polynucleotides (PN). A PN molecule is a biopolymer made up of 13 or more nucleotide monomers bonded together. If nucleotides sound familiar, it is because you probably heard about it in biology class – nucleotides are the basic structural units which make up DNA!

How Does Rejuran Healer Treatment Work?

The 2 main effects of Rejuran Healer, or PN/PDRN are:

  1. Wound healing – through stimulation of growth factors, increased microcirculation,

  2. Anti-inflammatory effects – through scavenging of free radicals and blockage of inflammatory cytokines in the body.


Rejuran does this through several mechanisms:

  1. PN/PDRN work by biologically increasing the metabolic activity of cells in the skin called fibroblasts – the fibroblasts in the skin are stimulated to regenerate key components of the skin which we lose with age, such as collagen, glycosaminoglycans and glycoproteins. In other words, PNs awaken tired aged cells to act younger and get to work again.

  2. PN/PDRN act mechanically as a scaffolding for cells and the extracellular matrix to grow – they have a 3-dimensional structure where fibroblasts can use to produce its regenerative effects.

  3. PN/PDRN provide building blocks for DNA synthesis. Through salvage pathways, the PNs are broken down by the body’s processes into purines and pyrimidines, then recycled into new DNA again.

What is the difference between PDRN vs PN?

Polynucleotides (PNs) refer to a broader group of molecules. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are all PNs. On the other hand, PRDN – Polydeoxyribonucleotides, refer to a subtype of PNs. Rejuran contains PNs – which also includes PDRN.

Mechanism-of-action-PDRN (1).jpg

What Benefits Does Rejuran Healer Have?

  1. Improved skin elasticity

  2. Improved Hydration

  3. Reduced fine lines and wrinkles

  4. Skin repair – with improved skin barrier function

  5. Skin normalization – thickening of skin, regulation of oil production

  6. Improved skin tone

  7. Improved skin texture

The conditions which Rejuran Healer have been shown to treat include:

  • Dark eye circles

  • Enlarged pores

  • Skin sagging

  • Enlarged pores

  • Dull skin

  • Wrinkles and fine lines

  • Acne scars

  • Stretch Marks


What Is the Treatment Process for Rejuran Healer?

Topical numbing cream is applied on the skin for 20 minutes. Your doctor then uses a fine needle to administer tiny amounts of Rejuran Healer under the skin. The treatment takes about 10 minutes to complete. In my practice, I also administer healing LED Red or Infrared Light to sooth the skin and reduce redness and swelling.


As Rejuran Healer treatment is essentially a skin healing procedure, it takes up to 4 weeks to see any visible improvements in your skin – this is because about 4 weeks for PDRN to take effect and repair the skin from the inside. The treatment is best done 3 to 4 times, 2 to 4 weeks apart. Best results are seen only after the last session. Afer that, treatments can be repeated once every 6 – 9 months for maintenance.

It is also important to understand that this is not a facial augmentation using dermal fillers, therefore you are unlikely to see any visible results.

To yield the full benefits of Rejuran Healer treatment, Dr. Siew advises that one should undergo a skin healing program of 3 sessions about 4 weeks apart. This is to ensure that the results are long-lasting and sustainable.

bottom of page