Hyaluronidase is made in Korea, KFDA approval. It is used to dissolve hyaluronic acid based dermal fillers that have been placed incorrectly, excessively, or unevenly. Hyaluronidase is also used in emergency situations where dermal filler has been inadvertently injected into an artery causing occlusion of the blood supply.

​

Hyaluronidase Ranidase Highly Purified Solutional Injection

Ranidase is highly purified hyaluronidase injection

​

Hyaluronidase is made in Korea, KFDA approval. It is used to dissolve hyaluronic acid based dermal fillers that have been placed incorrectly, excessively, or unevenly. Hyaluronidase is also used in emergency situations where dermal filler has been inadvertently injected into an artery causing occlusion of the blood supply.

Highly purified and safe hyaluronidase

​

Hyaluronidase is made in Korea. It is used to dissolve hyaluronic acid based dermal fillers that have been placed incorrectly, excessively, or unevenly. Hyaluronidase is also used in emergency situations where dermal filler has been inadvertently injected into an artery causing occlusion of the blood supply. It is injected into the vicinity of the dermal filler that needs to be dissolved.

Uses of Hyaluronidase Injection: To remove filler, hyaluronidase can be injected to dissolve the hyaluronic acid in dermal fillers. To increase the effect of lipodissoving injection, hyaluronidase can be added to the cocktails of fat melting injection.
Hyaluronidase is often combined with local anaesthetic to increase the diffusion of local anaesthetic.

Convenient

The Solutional hyaluronidase can be used directly to lesion site. All the others are freeze-dried powder, so has to be reconstituted before use.

​

Caution: There have been a few reports that some people may have an allergy to hyaluronidase, which happens to those who are allergic to bee stings.
 

​

Dosage

Adults, children, and elderly 1. In the case of subcutaneous injections (Hypodermoclysis) : The hyaluronidase can be injected into the affected area after dissolving about 1,500 I.U. of the agent into 1 mL of saline before starting a subcutaneous injection or, at the beginning of the injection, administer into the tube about 2 cm above the injection needle. About 1,500 I.U. of this drug is adequate when administering 500-1,000 mL of saline. For children and the elderly, please be careful in regulating the rate and total dosage, especially pay attention to overhydration if the subject has a renal impairment. 2. For subcutaneous or intramuscular injection : Dissolve 1,500 I.U. of this drug directly into the saline solution to be administered and use it. 3. Local anesthetic : Dissolve 1,500 I.U. of this drug into the local anesthetic injection to be administered and use it. When used in ophthalmology, a concentration of 15 I.U. per mL is recommended. 4. Extravasation : If diffusion is faster than in the case of focal, dissolve 1,500 I.U. of this drug into 1 mL of normal saline and soak the lesion after extravasation has displayed. 5. Hematoma : Dissolve 1,500 I.U. of this drug in 1 mL of injection solution or saline solution and soak the affected area. Dissolve this drug with about 1 mL of injection solution together with injections immediately before use. The subcutaneous injection should be isotonic with extracellular fluid in the body. This drug can be combined with commonly used fluids. Normal saline and Hypodermoclysis. Examples of use with 0.18% sodium chloride, 4% glucose, 0.45% sodium chloride, 2.5% glucose, and 5% glucose injection have been reported. 34 mmol/L Potassium is added to isotonic glucose or normal saline injection. Infusion solutions containing electrolytes are more suitable, and it should not be injected too quickly. This drug can be mixed with morphine, diamorphine, chlorpromazine, metoclopramide, chlorpromazine, metoclopramide, promazine, dexamethasone local anesthetic, and epinephrine.

 

 

Precautions for Use

1. Warning Ampoule injections have a risk of glass particles mixed with injections, which could cause adverse effects, so please pay close attention to minimize the risks. In particular, pay special attention when using it to children and the elderly (limited to glass ampoule injections). 2. Do not administer this drug to the following patients: 1) Patients with a history of a shock to this drug 2) Patients with hypersensitivity to this drug or bovine protein 3) Edema caused by being bitten or stung 4) In the vicinity of the affected area of infections diseases or cancer (could increase the permeability of the tissues and expand cancer or infection) 5) Anesthesia for early delivery with reasons unknown 6) Congenital heart disease patients, venous congestion patients 7) Patients with less than 5.5 g% serum protein 8) Nursing mother 3. Administer with care to the following patients : Patients with a history of drug hypersensitivity reactions 4. Adverse reaction : 1) Hypersensitivity reaction: Rarely, severe allergic reactions accompanied by shock may occur. 2) Administration area: In rare cases, local irritation, redness, pain, the spread of infection, bleeding, and bruising may appear. Edema has been reported in relation to hypodermoclysis. 3) Others: In rare cases, fever, tooth mobility, and menorrhagia may occur. 5. General Cautions 1) Allergic reactions may occur with very small portions. In order to predict reactions such as hypersensitivity reactions, it is advised to conduct a skin reaction test in advance with thorough consultation sessions. 2) Use the drug carefully under the due judgment of the doctor if the patient needs to drive or operate dangerous machinery during the treatment period. 6. Interaction 1) Heavy metal salts act as antagonists of this drug. 2) Combined with a formulation containing a salicylic acid derivative, the reabsorption effect of this drug may be reduced. 3) Do not consume alcohol during or immediately after taking this drug as it may enhance the action of alcohol. 4) Overdose of this drug may reduce the efficacy of topically applied drugs such as local anesthetics. 7. Administration to pregnant and nursing mothers 1) Since the safety of administering this drug during pregnancy has not been established, use the drug to women who are pregnant or potentially pregnant only when it is judged that the benefit of treatment exceeds the risks. 2) It is not known if this drug is transferred to breast milk, so do not use this drug to nursing mothers. 8. Administration to the elderly In general, the elderly have weaker physiological functions, so pay close attention to using the drug. e.g., reducing the dosage 9. Treatment in case of overdose 1) Symptoms: Nausea, redness, hives, rapid pulse (tachycardia), the difficulty of breathing, shock, and respiratory arrest may occur. 2) Treatment: Stop the administration of this drug. If the patient experiences skin symptoms such as redness or hives, administer antihistamines. If the patient experiences rapid pulse (tachycardia), administer corticosteroids intravenously. In case of shock, administer epinephrine, supply oxygen, inject corticosteroids intravenously, and retain airways. In case of respiratory arrest, perform CPR. 10. Notes on Application 1) Prepare as a solution and use it immediately. 2) Do not administer directly into the cornea or joint as it may cause swelling. 3) Do not inject intravenously. 4) The combination of heparin and epinephrine is physically inappropriate (becomes murky). However, in clinical practice, it can be used by mixing with a very small concentration of epinephrine without any problems. This drug is not to be combined with furosemide, benzodiazepines, phenytoin, chondroitin sulfate B containing sulfonic acid salts surfactants, or bile salts. 5) This drug is not to be used to promote the diffusion or absorption of alpha-blockers or dopamine drugs.